The obligate intracellular bacterium Orientia tsutsugamushi differentiates into a developmentally distinct extracellular state

The obligate intracellular bacterium Orientia tsutsugamushi differentiates into a developmentally distinct extracellular state

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Orientia tsutsugamushi (Ot) the causing agent of scrub typhus exits infected cells using a unique mechanism that involves budding off the surface of infected cells.Here, Atwal COLOUR BATH GREEN et al.report that Ots that have budded from their host cells are in a distinct developmental stage Integrated Fridge/Freezers than intracellular bacteria and provide the first characterization of this extracellular stage.Both forms are infectious but differ in their physical properties, proteome, and entry mechanism into host cells.